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Long after a pandemic swept the world, society has crumbled. A remnant of human civilization ekes out an existence in a closed community called Sanctuary. To control their population, the ruling brethren use a lottery, the winners of which join the new Gods that reside beyond the walls. But when her daughter is chosen, Anna Charles discovers the lottery is fixed by despotic church leader, Roman Quail. Now in a frantic bid to save her family, she flees into the hostile environment outside Sanctuary where only the strongest survive, and where all their Gods are dead. Literally.